Background: Monday, Wednesday, and Friday dosing of rosuvastatin in patients previously intolerant to statin therapy. Backes JM, Venero CV, Gibson CA, Ruisinger JF, Howard PA, Thompson PD, Moriarty PM. 1. The once-a-week schedule was tolerated by 74% of the patients with doses ranging from 2.5 to 20 mg once weekly. 2008 Mar;42(3):341-6. doi: 10.1345/aph.1K604. The specific dosage used for each patient was based primarily on each patient's prior history of statin use and the severity of the adverse events that they developed. If you have to take statins, please use the lowest dose possible. Clin Ther. Once-a-week rosuvastatin (2. Is an Even Safer Combined Oral Contraceptive Pill Available? Patients with lipid levels measured 1-3 days and 4-7 days after receiving their last rosuvastatin dose had similar mean LDL-C reductions. Synopsis: Once-a-week rosuvastatin therapy was well tolerated in patients with a history of adverse events to one or more statins and led to significantly improved lipoprotein changes. Efficacy of rosuvastatin (5 mg and 10 mg) twice a week in patients intolerant to daily statins. J Am Pharm Assoc 2005;45: 503-513. ReliasMedia_AR@reliasmedia.com, Do Not Sell My Personal Information  Privacy Policy  Terms of Use  Contact Us  Reprints  Group Sales, For DSR inquiries or complaints, please reach out to Wes Vaux, Data Privacy Officer, DPO@relias.com, Design, CMS, Hosting & Web Development :: ePublishing, New contraceptives widen choices, but the Pill still is a top selection, Statin Use Is Associated With a Lower Risk of Community-acquired. Patients tolerating the once-a-week regimen experienced a 17% reduction in total cholesterol, 23% reduction in low-density lipoprotein cholesterol, 12% reduction in triglycerides, and a 5% increase in high-density lipoprotein … Clipboard, Search History, and several other advanced features are temporarily unavailable. Dr. Karpman reports no financial relationship to this field of study. 5. Weekly dosing has the potential to lower costs and increase convenience while maintaining a similar effect on lipids. SLCO1B1 Polymorphisms and Statin-Induced Myopathy. Ann Pharmacother. Be diligent about putting back the nutrients that statins interfere with such as the coenzyme Q10, selenium, and vitamin K2, along with other heart healthy nutrients. Lopez LM. A significant difference in the mean percentage change in LDL from baseline for rosuvastatin vs. placebo was identified (12.2% reduction vs. 0.4% reduction, respectively; P = .002).  |  Rosuvastatin once a week was tolerated by 37 (74%) of the 50 study participants, with doses ranging from 2.5 mg to 20 mg a week (mean 10 +/- 4 mg). 2. 1-800-370-9210 Rosuvastatin 5 and 10 mg/d: a pilot study of the effects in hypercholesterolemic adults unable to tolerate other statins and reach LDL cholesterol goals with nonstatin lipid-lowering therapies. Glueck CJ, Aregawi D, Agloria M, Khalil Q, Winiarska M, Munjal J, Gogineni S, Wang P. Clin Ther. Atorvastatin is a potent antihyperlipidemic but is quite expensive, costing up to $700 for a 1-year supply of 10-mg tablets in retail pharmacies. Epub 2008 Feb 19. Results: A new study tracked how they did. Am J Cardiol 2003;92:152-160. Am J Cardiol 2007;99:291. 2004 Sep;26(9):1368-87. doi: 10.1016/j.clinthera.2004.09.005. Please enable it to take advantage of the complete set of features! Is There a Link Between Miscarriage and Future Cardiovascular Disease? Effectiveness and tolerability of every-other-day rosuvastatin dosing in patients with prior statin intolerance. There are exceptions to taking these nutrients so ask your doctor (yes, the same one that gave you the statin.) Rosuvastatin: a review of its use in the prevention of cardiovascular disease in apparently healthy women or men with normal LDL-C levels and elevated hsCRP levels. Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR* trial). The lipid-lowering effects of once-a-week rosuvastatin proved to be statistically significant; however, no attempt was made to determine whether this alternative dosing regimen was capable of reducing cardiovascular events over the course of this relatively short-term study. 3. 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